ZNF808
Description
The ZNF808 (zinc finger protein 808) is a protein-coding gene located on chromosome 19.
ZNF808 is a transcriptional repressor that primarily targets transposable elements, particularly the long terminal repeat of endogenous retroviruses classified as MER11 elements (subfamilies A, B, and C). This repression is achieved through the establishment of heterochromatin-associated trimethylation of histone H3 at lysine 9 (H3K9me3). ZNF808 can also bind to gene promoters and other genomic regions. During early pancreas development, ZNF808 represses transcription of specific MER11 elements during differentiation toward pancreatic lineages. By doing so, it prevents aberrant activation of a liver gene expression program during pancreas differentiation.
ZNF808 is also known as -.
