ZNF730
Description
The ZNF730 (zinc finger protein 730) is a protein-coding gene located on chromosome 19.
ZNF730, also known as zinc finger protein 730, is a protein encoded by the ZNF730 gene in humans. Located on the short arm of chromosome 19, ZNF730 is believed to play a role in transcriptional regulation, particularly in acute myeloid leukemia and endometrial cancer. This speculation stems from its higher expression levels in endometrial cancerous tumor samples and its identification as a core binding factor in acute myeloid leukemia. ZNF730 is a C2H2-type zinc finger protein, characterized by its β/β/α structure stabilized by a zinc ion. The C2H2-type protein motifs are known to regulate transcription by recognizing and binding to DNA sequences.
The human ZNF730 gene spans 5533 nucleotides and encodes the longest isoform, transcript variant 1. It resides at the 19p12 locus on the plus strand of chromosome 19 and comprises 14 exons. The gene encodes one Kruppel Associated Box (KRAB) and 12 C2H2 Zinc Fingers.
The mRNA isoform 1 encoded by the human ZNF730 gene is 514 nucleotides long.
ZNF730 is also known as -.
