ZNF705E
The ZNF705E Gene: A Comprehensive Guide
Description
The ZNF705E gene is located on chromosome 19q13.42 and encodes a protein called zinc finger protein 705E (ZNF705E). ZNF705E is a member of the Kruppel-like factor (KLF) family of transcription factors, which play a role in regulating gene expression. ZNF705E is specifically involved in the regulation of cell proliferation, differentiation, and apoptosis.
Associated Diseases
Mutations in the ZNF705E gene have been linked to a variety of diseases, including:
- Polycythemia vera (PV): A blood cancer characterized by an abnormally high number of red blood cells.
- Essential thrombocythemia (ET): A blood cancer characterized by an abnormally high number of platelets.
- Myelofibrosis (MF): A blood cancer characterized by the formation of scar tissue in the bone marrow.
- Leukemia: A cancer of the blood and bone marrow.
- Solid tumors: ZNF705E mutations have also been implicated in the development of certain solid tumors, such as breast cancer, lung cancer, and colon cancer.
Did you Know ?
ZNF705E mutations are found in approximately 20% of PV patients, 5% of ET patients, and 10% of MF patients.
