ZNF658
Description
The ZNF658 (zinc finger protein 658) is a protein-coding gene located on chromosome 9.
ZNF658 is a zinc-responsive transcription factor that represses gene expression. It binds to a specific DNA sequence called the zinc transcriptional regulatory element (ZTRE) found in the promoter regions of its target genes. This binding leads to the repression of gene expression, including genes involved in zinc transport (SLC30A5 and SLC30A10) and other cellular processes (CBWD1). ZNF658 may also play a role in controlling ribosome biogenesis by regulating the levels of ribosomal RNA (rRNA) and ribosomal proteins. This regulation helps coordinate ribosome production with the availability of zinc, which is essential for ribosome function.
ZNF658 is also known as -.
Associated Diseases
- glycogen storage disorder due to hepatic glycogen synthase deficiency
- diabetes mellitus, permanent neonatal 4
- diabetes mellitus, transient neonatal, 3
- permanent neonatal diabetes mellitus 1
