ZNF451
Description
The ZNF451 (zinc finger protein 451) is a protein-coding gene located on chromosome 6.
Zinc finger protein 451 is a novel nuclear protein that in humans is encoded by the ZNF451 gene.
ZNF451 is an E3 SUMO-protein ligase that preferentially attaches SUMO2 and SUMO3 to target proteins, a process aided by the enzyme UBE2I/UBC9. It plays a role in SUMO2 modification in response to cellular stress caused by DNA damage or proteasome inhibition. ZNF451 is essential for the sumoylation of MCM4. It does not interact with SUMO1. ZNF451 primarily adds a SUMO2 chain to the SUMO2 consensus site ‘Lys-11‘. This ligase negatively regulates transcriptional activation by the SMAD4 complex in response to TGF-beta signaling. It also inhibits EP300-mediated acetylation of histone H3 at ‘Lys-9‘, thereby impacting gene transcription. ZNF451 plays a role in regulating the transcription of androgen receptor (AR) target genes.
ZNF451 is also known as COASTER, ZATT, dJ417I1.1.
