ZNF445
Description
The ZNF445 (zinc finger protein 445) is a protein-coding gene located on chromosome 3.
ZNF445 is a transcription regulator crucial for maintaining imprinting, a process that regulates gene expression based on parental origin. It achieves this by controlling DNA methylation during early development at multiple imprinting control regions (ICRs). While ZNF445 collaborates with ZFP57, it appears to be the primary factor in human embryonic imprinting maintenance. In contrast, ZFP57 is the dominant factor in mice.
ZNF445 is also known as ZFP445, ZKSCAN15, ZNF168, ZSCAN47.
Associated Diseases
- retinitis pigmentosa and erythrocytic microcytosis
- X-linked retinal dysplasia
- IRIDA syndrome
- Rh deficiency syndrome
- overhydrated hereditary stomatocytosis
- major depressive disorder
- motor developmental delay due to 14q32.2 paternally expressed gene defect
- Dravet syndrome
- uterine cancer
