ZNF432
Description
The ZNF432 (zinc finger protein 432) is a protein-coding gene located on chromosome 19.
ZNF432 is a protein that plays a role in DNA damage repair. It acts as a reader of poly(ADP-ribose) (PAR) and regulates the DNA damage response by inhibiting PARP activity. ZNF432 is recruited to DNA lesions in a PAR-dependent manner, where it stimulates PARP1 activity. It also preferentially binds to single-stranded DNA (ssDNA) and inhibits EXO1-mediated resection, likely through a PAR-independent mechanism.
ZNF432 is also known as -.
Associated Diseases
- Shwachman-Diamond syndrome
- atypical hemolytic-uremic syndrome with C3 anomaly
- atypical hemolytic-uremic syndrome with I factor anomaly
- atypical hemolytic-uremic syndrome with MCP/CD46 anomaly
- atypical hemolytic-uremic syndrome with thrombomodulin anomaly
- tubulointerstitial kidney disease, autosomal dominant, 2
- atypical hemolytic-uremic syndrome with B factor anomaly
- congenital dyserythropoietic anemia type 4
- thrombocytopenia-absent radius syndrome
- microcephaly-cervical spine fusion anomalies syndrome
- paroxysmal nocturnal hemoglobinuria
- glioblastoma
