ZNF304
Description
The ZNF304 (zinc finger protein 304) is a protein-coding gene located on chromosome 19.
ZNF304 is a zinc finger protein that plays a role in gene silencing and transcriptional regulation. It is involved in tumor suppression and embryonic stem cell development. ZNF304 also promotes angiogenesis, tumor growth and metastasis.
ZNF304, also known as KRAB-containing zinc finger protein, acts as a transcriptional regulator and plays a role in gene silencing. It forms a corepressor complex that is required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. ZNF304 is also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of ‘Lys-27‘ of histone H3 (H3K27me3) in a Polycomb group (PcG) complexes-dependent manner. ZNF304 associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites. ZNF304 also acts as a transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways. ZNF304 associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression. ZNF304 promotes angiogenesis and tumor growth.
ZNF304 is also known as -.
