ZNF274
Description
The ZNF274 (zinc finger protein 274) is a protein-coding gene located on chromosome 19.
ZNF274 is a protein encoded by the ZNF274 gene in humans. It contains five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. It is suggested to be a transcriptional repressor and is primarily located in the nucleolus. Alternative splicing generates different isoforms, with variations in polyadenylation signals.
ZNF274 is a probable transcription repressor that specifically binds to the 3‘-end of zinc-finger coding genes. It recruits chromatin-modifying proteins like SETDB1 and TRIM28/KAP1, leading to transcription repression. The complex formed by SETDB1, TRIM28, and ZNF274 might be involved in recruiting ATRX to the 3‘-exons of zinc-finger coding genes with unusual chromatin signatures, contributing to the establishment, maintenance, or protection of H3K9me3 at these transcriptionally active regions.
ZNF274 is also known as HFB101, ZF2, ZKSCAN19, ZSCAN51.
