ZNF219
Description
The ZNF219 (zinc finger protein 219) is a protein-coding gene located on chromosome 14.
Zinc finger protein 219 is a protein encoded by the ZNF219 gene in humans. It is a transcriptional regulator that binds to specific DNA sequences.
ZNF219 acts as a transcriptional regulator, recognizing and binding to two copies of the DNA sequence 5‘-GGGGG-3‘. It represses the expression of HMGN1 by binding to its promoter. ZNF219 also regulates SNCA expression in cortical neurons. Additionally, it interacts with SOX9 and activates COL2A1 expression by binding to its promoter. This suggests a role for ZNF219 in chondrocyte differentiation.
ZNF219 is also known as ZFP219.
