ZNF207
Description
The ZNF207 (zinc finger protein 207) is a protein-coding gene located on chromosome 17.
Zinc finger protein 207 is a protein in humans that is encoded by the ZNF207 gene.
ZNF207 is a kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. It forms liquid droplets through phase transition or coacervation, which promotes microtubule bundling and tubulin concentration, facilitating microtubule polymerization and spindle formation. ZNF207 also regulates mitotic chromosome alignment by stabilizing BUB3 and promoting its kinetochore loading. The exact mechanism of BUB3 stabilization is unclear, but it may involve blocking its ubiquitination and proteasomal degradation.
ZNF207 is also known as BuGZ, hBuGZ.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- Alzheimer disease
- lysosomal storage disease
- schizophrenia
- substance abuse
- hemoglobin E-beta-thalassemia syndrome
- dehydrated hereditary stomatocytosis
- gluthathione peroxidase deficiency
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- megaloblastic anemia, folate-responsive
- IRIDA syndrome
- hemochromatosis type 5
