ZG16
Description
The ZG16 (zymogen granule protein 16) is a protein-coding gene located on chromosome 16.
Zymogen Granule Protein 16 is a protein encoded by the ZG16 gene. Other names include hZG16, FLJ43571, FLJ92276, secretory lectin ZG16, jacalin-like lectin domain containing, JCLN, JCLN1, MGC183567, MGC34820, ZG16A, zymogen granule membrane protein 16, zymogen granule protein 16 homolog, and zymogen granule protein. The gene is located on Chromosome 16: 29,778,256-29,782,973. The gene has one transcript (one splice variant) and 128 orthologues.
ZG16 facilitates protein transport, protein trafficking, carbohydrate binding, and peptidoglycan binding. Zymogen Granule Protein 16 acts as a linker molecule between the secretory proteins in the trans-Golgi network (TGN) and the zymogen granule membrane (ZGM). The protein is found in the Golgi lumen and collagen-containing extracellular matrix. ZG16 is highly specific for cytoplasmic expression in mucin-producing goblet cells, which are located in the gastrointestinal tract. These cells produce mucus to protect mucous membranes lining the surface of internal organs. The protein is mainly expressed in the human colon, endometrium, and spleen.
ZG16 is also known as JCLN, JCLN1, ZG16A.
Associated Diseases
- colorectal cancer
- isolated agammaglobulinemia
- mannose-binding lectin deficiency
- immunodeficiency due to ficolin3 deficiency
- MHC class II deficiency
- hyper-IgM syndrome type 2
- autosomal recessive severe congenital neutropenia due to JAGN1 deficiency
- cancer
- pancreatic ductal adenocarcinoma
