ZFYVE19
Description
The ZFYVE19 (zinc finger FYVE-type containing 19) is a protein-coding gene located on chromosome 15.
Zinc finger FYVE domain-containing protein 19 is a protein that in humans is encoded by the ZFYVE19 gene.
ZFYVE19 plays a crucial role in the abscission step of cytokinesis, the final stage of cell division. It functions as part of the cytokinesis checkpoint, a mechanism that prevents premature cell separation before chromosome bridges are resolved and DNA damage is minimized. ZFYVE19, in collaboration with CHMP4C, ensures that VPS4 (VPS4A and/or VPS4B), a protein essential for abscission, remains at the midbody ring until the cytokinesis checkpoint is deactivated. This retention is achieved through a complex interaction where CHMP4C binds to ZFYVE19 and VPS4. The deactivation of AURKB, a kinase involved in cell cycle regulation, triggers the dephosphorylation of CHMP4C, leading to its dissociation from ZFYVE19 and VPS4. This dissociation, in turn, initiates the abscission process, allowing the cell to divide completely.
ZFYVE19 is also known as ANCHR, MPFYVE, PFIC9.
