ZFY
Description
The ZFY (zinc finger protein Y-linked) is a protein-coding gene located on chromosome Y.
The ZFY gene, located on the Y chromosome, encodes a zinc finger protein that likely functions as a transcription factor. It was once thought to be the testis-determining factor (TDF) but was later found to be incorrect. Humans have a single ZFY gene with two splice variants, while mice have two copies, Zfy1 and Zfy2. Proper expression of Zfy genes is crucial for spermatogenesis, as incorrect expression leads to programmed cell death (apoptosis) at a specific stage of sperm development. Zfy genes are also essential for meiotic sex chromosome inactivation (MSCI), a process that silences sex chromosomes during meiosis. The ZFY gene is primarily expressed in the testis and prostate, but it is also found in other tissues, including the esophagus, urinary bladder, bone marrow, small intestine, appendix, and gall bladder. Disorders associated with the ZFY gene include campomelic dysplasia, cystadenofibroma, and Frasier syndrome.
ZFY is also known as ZNF911.
Associated Diseases
- familial primary pulmonary hypoplasia
- male infertility with teratozoospermia due to single gene mutation
- pyknoachondrogenesis
- spermatogenic failure 8
- partial chromosome Y deletion
- spermatogenic failure 51
- spermatogenic failure 65
- spermatogenic failure, X-linked, 3
- spermatogenic failure 39
- spermatogenic failure 40
- spermatogenic failure 48
- spermatogenic failure 72
- spermatogenic failure 47
- spermatogenic failure 25
- spermatogenic failure 1
- spermatogenic failure 41
- amyotrophic lateral sclerosis
- spermatogenic failure 42
