ZDHHC19
Description
The ZDHHC19 (zinc finger DHHC-type palmitoyltransferase 19) is a protein-coding gene located on chromosome 3.
ZDHHC19 is a palmitoyltransferase that modifies proteins like RRAS and SQSTM1. It increases RRAS palmitoylation, leading to better cell survival. ZDHHC19 enhances autophagy by modifying SQSTM1, which improves the interaction of SQSTM1 with ATG8 proteins and recruits ubiquitinated cargo to autophagosomes.
ZDHHC19 is also known as DHHC19.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 72
- spermatogenic failure 46
- spermatogenic failure 27
- spermatogenic failure 18
- spermatogenic failure 65
- spermatogenic failure 19
- spermatogenic failure 43
