ZCCHC18
Description
The ZCCHC18 (zinc finger CCHC-type containing 18) is a protein-coding gene located on chromosome X.
Zinc finger CCHC-type containing 18 (ZCCHC18) is a protein that in humans is encoded by ZCCHC18 gene. It is also known as Smad-interacting zinc finger protein 2 (SIZN2), para-neoplastic Ma antigen family member 7b (PNMA7B), and LOC644353. Other names such as zinc finger, CCHC domain containing 12 pseudogene 1, P0CG32, ZCC18_HUMAN had been used to describe this protein. ZCCHC18 belongs to the ZCCHC12 family or para-neoplastic Ma (PNMA). It is a ligand-dependent nuclear receptor transcription coactivator. Its zinc finger domain is CCHC which binds to zinc ion (see protein section for detail information on CCHC motif). It is worthwhile to mention that in mammals, PNMA is derived from Ty3/Gypsy long terminal repeat (LTR) retrotransposons and PNMA family encodes the Gag-like protein. Although the full functions remain unknown, most PNMA genes are expressed in brains of macaques and mice. PNMA1, 2 and 3 were found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, having a role in death receptor-dependent apoptosis.
ZCCHC18 acts as a ligand-dependent nuclear receptor transcription coactivator. This protein belongs to the ZCCHC12 family or para-neoplastic Ma (PNMA), which is derived from Ty3/Gypsy long terminal repeat (LTR) retrotransposons. PNMA genes are primarily expressed in brains of macaques and mice, and some members, like PNMA1, 2, and 3, are found in the serum of patients with paraneoplastic neurological disorders. The PNMA family also includes modulator of apoptosis 1, which plays a role in death receptor-dependent apoptosis. While the complete functions of ZCCHC18 remain to be fully understood, its role as a transcription coactivator suggests its involvement in regulating gene expression in response to specific signals.
ZCCHC18 is also known as PNMA7B, SIZN2.
