ZBTB7B
Description
The ZBTB7B (zinc finger and BTB domain containing 7B) is a protein-coding gene located on chromosome 1.
Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene. ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g. COL1A1; MIM 120150) and has a role in development.[supplied by OMIM]
ZBTB7B is a transcription regulator that plays a critical role in the development of immune cells, particularly in the commitment of immature T-cell precursors to either the CD4+ helper or CD8+ killer T-cell lineages. Its function is essential for CD4+ lineage commitment, while its absence results in CD8+ commitment. ZBTB7B directly regulates the expression of genes involved in T-cell development and function, including the suppressor of cytokine signaling (SOCS) genes, which are key players in the CD4+ lineage fate decision. ZBTB7B also acts as a negative regulator of the CD8 promoter and enhancers, suppressing their expression by recruiting histone deacetylases, such as HDAC4 and HDAC5, to these loci. In addition to its role in T-cell development, ZBTB7B functions as a key metabolic regulator in the lactating mammary glands, regulating insulin signaling and the expression of insulin receptor substrate-1 (IRS-1), which is critical for mammary gland lactation. ZBTB7B also influences the development of IL17-producing CD1d-restricted natural killer (NK) T cells, demonstrating its broader impact on immune cell development. Furthermore, ZBTB7B has been implicated in brown fat development, thermogenesis, and beige fat formation.
ZBTB7B is also known as CKROX, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, vGAF.
