ZBTB32
Description
The ZBTB32 (zinc finger and BTB domain containing 32) is a protein-coding gene located on chromosome 19.
Zinc finger and BTB domain-containing protein 32 is a protein that in humans is encoded by the 1960 bp ZBTB32 gene. The 52 kDa protein (487 aa) is a transcriptional repressor and the gene is expressed in T and B cells upon activation, but also significantly in testis cells. It is a member of the Poxviruses and Zinc-finger (POZ) and Krüppel (POK) family of proteins, and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development. The protein recruits histone modification enzymes to chromatin to affect gene activation. ZBTB32 recruits corepressors, such as N-CoR and HDACs to its target genes, induces repressive chromatin states and acts cooperatively with other proteins, e.g. with Blimp-1, to suppress the transcription of genes . It contains a N-terminal BTB/POZ domain (IPR000210) or a SKP1/BTB/POZ domain (IPR011333), and three C-terminal zinc fingers, Znf_C2H2_sf. (IPR036236), Znf_C2H2_type domain (IPR013087), a Znf_RING/FYVE/PHD domain (IPR013083), followed by a putative UBZ4 domain.
== Nomenclature == Zinc finger and BTB domain-containing protein 32 is also known as:
Fanconi Anemia Zinc Finger Protein (FAZF), Testis Zinc Finger Protein (TZFP), FANCC-Interacting Protein (FAXP), Zinc Finger Protein 538 (ZNF538), Repressor of GATA3 (ROG), Promyelocytic Leukemia Zinc Finger and Zbtb16 (PLZF)-like zinc finger protein (PLZP)
== Interactions == Zbtb32 has been shown to interact with:
Fanconi anemia complementation group C (Fancc) Thioredoxin interacting protein (Txnip), but the interaction might be unspecific; however, Vitamin D3 upregulated protein 1 (VDUP1) seems to interact Zinc finger and BTB domain-containing protein 16 (Zbtb16) Zinc-finger elbow-related proline domain protein 2 (Zpo2) GATA binding protein (Gata2)
== Immune system == The expression of ZBTB32 is induced by inflammatory cytokines and promotes proliferation of natural killer cells. Zbtb32 knockout mice show a trend to develop type 1 diabetes, although the difference is not statistically different.
ZBTB32 binds to the DNA sequence 5'-TGTACAGTGT-3' and can act as both a transcriptional activator and repressor. It likely prevents GATA3 from binding to DNA, contributing to its repressor function. ZBTB32 may play a role in regulating the differentiation and activation of helper T cells.
ZBTB32 is also known as FAXF, FAZF, Rog, TZFP, ZNF538, mynn.
