YWHAB
Description
The YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) is a protein-coding gene located on chromosome 20.
The YWHAB gene encodes a protein belonging to the 14-3-3 family of proteins, which are involved in signal transduction by binding to proteins containing phosphoserine. This highly conserved protein family is found in both plants and mammals. The encoded protein interacts with RAF1 and CDC25 phosphatases, suggesting a potential role in connecting mitogenic signaling and the cell cycle machinery. Two transcript variants, encoding the same protein, have been identified for this gene.
YWHAB (14-3-3 protein beta/alpha) acts as an adapter protein, playing a key role in regulating a diverse range of signaling pathways both general and specialized. It interacts with numerous partners, primarily through recognition of phosphorylated serine or threonine residues. These interactions typically modulate the activity of the bound partner. YWHAB acts as a negative regulator of bone formation (osteogenesis). It prevents the phosphorylated form of SRPK2 (by AKT1) from entering the nucleus, counteracting its stimulatory effects on cyclin D1 expression and ultimately blocking SRPK2-induced neuronal apoptosis. Furthermore, it negatively regulates signaling pathways that activate MAP kinases via AKAP13.
YWHAB is also known as GW128, HEL-S-1, HS1, KCIP-1, YWHAA.
Associated Diseases
- cancer
- Noonan syndrome
- Costello syndrome
- COVID-19
- ovarian cancer
- esophageal cancer
- Alzheimer disease
- multiple sclerosis
- Parkinson disease
- lysosomal storage disease
