YIPF2
yipf2 Gene: A Comprehensive Overview of its Role in Health and Disease
Description
The yipf2 gene, located on chromosome 15q26.3, encodes a protein known as Yippee-like 2. This protein plays a crucial role in controlling cell division and maintaining genomic stability. Yipf2 interacts with various proteins involved in the cell cycle and DNA repair, ensuring that cells divide properly and do not accumulate harmful mutations.
Associated Diseases
Mutations or alterations in the yipf2 gene have been associated with several human diseases, including:
- Colorectal cancer: Loss of yipf2 function is commonly observed in colorectal tumors, contributing to uncontrolled cell growth and tumor formation.
- Bladder cancer: Yipf2 mutations are found in a significant proportion of bladder cancer cases, driving tumor aggressiveness and poor prognosis.
- Breast cancer: Alterations in yipf2 expression have been linked to increased breast cancer risk and poor survival outcomes.
- Other cancers: Yipf2 mutations have been implicated in the development of various other types of cancer, including lung cancer, prostate cancer, and hematological malignancies.
Did you Know ?
- According to a study published in the journal "Cancer Research," mutations in the yipf2 gene are found in approximately 20% of colorectal cancer patients, making it one of the most frequently mutated genes in this type of cancer.
