YES1
Description
The YES1 (YES proto-oncogene 1, Src family tyrosine kinase) is a protein-coding gene located on chromosome 18.
YES1, the human homolog of the Yamaguchi sarcoma virus oncogene, encodes a non-receptor tyrosine kinase with tyrosine kinase activity and belongs to the src family. It lies near the thymidylate synthase gene on chromosome 18, with a pseudogene on chromosome 22. YES1 interacts with Janus kinase 2, CTNND1, RPL10, and Occludin.
YES1, also known as Proto-oncogene c-Yes or p61-Yes, is a non-receptor protein tyrosine kinase involved in various cellular processes. It plays a role in regulating cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Activation by receptor tyrosine kinases (RTKs), including EGFR, PDGFR, CSF1R, and FGFR, leads to YES1 recruitment to the phosphorylated receptor, activating downstream substrates. Upon EGFR activation, YES1 promotes phosphorylation of PARD3, facilitating epithelial tight junction assembly. It participates in the phosphorylation of specific junctional components like CTNND1 by stimulating FYN and FER tyrosine kinases at cell-cell contacts. In T-cell stimulation by CXCL12, YES1 phosphorylates collapsin response mediator protein 2/DPYSL2, inducing T-cell migration. YES1 also participates in CD95L/FASLG signaling pathway, mediating AKT-mediated cell migration. It plays a crucial role in cell cycle progression by phosphorylating cyclin-dependent kinase 4/CDK4, regulating the G1 phase. YES1 is also involved in G2/M progression and cytokinesis. Furthermore, it catalyzes the phosphorylation of organic cation transporter OCT2, inducing its transport activity.
YES1 is also known as HsT441, P61-YES, Yes, c-yes.
