XCL2
Description
The XCL2 (X-C motif chemokine ligand 2) is a protein-coding gene located on chromosome 1.
XCL2 is a small protein (cytokine) that belongs to the XC chemokine family. It is closely related to another chemokine called XCL1. XCL2 is mainly produced by activated T cells (a type of lymphocyte), but can also be found in small amounts in inactive T cells. XCL2 attracts cells that have the XCR1 receptor on their surface. The gene for XCL2 is located on chromosome 1 in humans.
XCL2 attracts lymphocytes (a type of white blood cell) but does not attract monocytes or neutrophils (other types of white blood cells).
XCL2 is also known as SCM-1b, SCM1B, SCYC2.
Associated Diseases
- ovarian cancer
- cancer
- systemic lupus erythematosus
- autoinflammatory syndrome with immunodeficiency
- severe combined immunodeficiency due to IKK2 deficiency
- complement component C1s deficiency
- combined immunodeficiency due to partial RAG1 deficiency
- autoinflammatory syndrome, familial, Behcet-like 1
