WWP2
Description
The WWP2 (WW domain containing E3 ubiquitin protein ligase 2) is a protein-coding gene located on chromosome 16.
WWP2 is a human gene that encodes a member of the NEDD4-like protein family, known for their ubiquitin-protein ligase activity. The protein contains 4 WW domains, which are protein motifs involved in protein-protein interactions. Three isoforms of WWP2 exist, generated by alternative splicing. In neurons, the mouse ortholog of WWP2, Wwp2, and its homolog Wwp1 regulate axon polarity, formation, and branching, as well as the migration of newly born nerve cells. WWP2 interacts with proteins like SCNN1B and ATN1. Full-length WWP2, as well as its N-terminal (WWP2-N) and C-terminal (WWP2-C) isoforms, bind to SMAD proteins.
WWP2 is an E3 ubiquitin ligase that accepts ubiquitin from an E2 enzyme and transfers it to target proteins. It polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation, leading to its degradation and potentially regulating POU5F1 levels in embryonic stem cells. It also ubiquitinates EGR2, promoting its degradation and inhibiting activation-induced cell death in T-cells. WWP2 can ubiquitinate SLC11A2, a process enhanced by NDFIP1 and NDFIP2. Additionally, it ubiquitinates RPB1, promoting its degradation.
WWP2 is also known as AIP2, WWp2-like.
