WTIP
Description
The WTIP (WT1 interacting protein) is a protein-coding gene located on chromosome 19.
WTIP is a Community-based Public Radio formatted broadcast radio station licensed to Grand Marais, Minnesota, serving Cook County, Minnesota. WTIP is owned and operated by Cook County Community Radio Corporation. In addition to the main station, WTIP is relayed by two full power translators to widen its broadcast area and cover all of Cook County, Minnesota.
WTIP is a protein that acts as an adapter or scaffold, helping to assemble various protein complexes. It plays a crucial role in multiple cellular processes, including cell fate determination, cytoskeletal organization, gene transcription repression, cell-cell adhesion, differentiation, proliferation, and migration. WTIP positively regulates microRNA-mediated gene silencing and negatively regulates the Hippo signaling pathway, inhibiting phosphorylation of YAP1. It acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG, suppressing E-cadherin transcription. WTIP also functions as a hypoxic regulator by bridging prolyl hydroxylases and VHL, enabling efficient degradation of HIF1A. In podocytes, WTIP might regulate actin dynamics and foot process cytoarchitecture. During podocyte injury, it translocates to the nucleus and represses WT1-dependent transcription, linking changes in slit diaphragm structure to altered gene expression and a less differentiated phenotype. WTIP is also involved in basal body organization and cilia growth and positioning.
WTIP is also known as -.
Associated Diseases
- familial idiopathic steroid-resistant nephrotic syndrome
- proteinuria, chronic benign
- nail-patella-like renal disease
- nephrotic syndrome 16
- lipoprotein glomerulopathy
- uridine-cytidineuria
- focal segmental glomerulosclerosis 7
- Dent disease
- hyperprolinemia type 1
- focal segmental glomerulosclerosis 5
- isolated sedoheptulokinase deficiency
- glomerulopathy with fibronectin deposits 2
- myoglobinuria, recurrent
- familial steroid-resistant nephrotic syndrome with sensorineural deafness
- congenital nephrotic syndrome, Finnish type
- autosomal dominant progressive nephropathy with hypertension
- paroxysmal nocturnal hemoglobinuria 1
