WTAP
Description
The WTAP (WT1 associated protein) is a protein-coding gene located on chromosome 6.
WTAP is a human gene. It is a pre-mRNA splicing regulator and is part of the WMM complex, which is involved in RNA methylation. WTAP is required for the accumulation of METTL3 and METTL14 in nuclear speckles. It also regulates the G2/M cell cycle transition and interacts with WT1.
WTAP is a component of the WMM complex, which is responsible for N6-methyladenosine (m6A) methylation of RNAs. This modification plays a role in mRNA splicing and RNA processing. WTAP is required for the accumulation of METTL3 and METTL14 in nuclear speckles. It acts as a mRNA splicing regulator. WTAP also regulates the G2/M cell cycle transition by binding to the 3'UTR of CCNA2, which enhances its stability. Additionally, WTAP impairs WT1 DNA-binding ability and inhibits the expression of WT1 target genes.
WTAP is also known as Mum2.
Associated Diseases
- microphthalmia with limb anomalies
- isolated asymptomatic elevation of creatine phosphokinase
- cancer
- pentosuria
- urinary bladder carcinoma
