WNT7B
Description
The WNT7B (Wnt family member 7B) is a protein-coding gene located on chromosome 22.
WNT7B is a signaling protein crucial for various developmental processes, including the formation of the placenta, lungs, eyes, dendrites, and bones, as well as kidney development. Its primary function is to establish the cortico-medullary axis of the kidney, which is the organization of the kidney's outer and inner layers. WNT7B is a member of the WNT gene family, which encodes secreted signaling proteins involved in cancer development and embryonic development. WNT7B shares a high degree of similarity with other WNT proteins, particularly WNT7A, and is believed to play a role in the development and progression of certain cancers like gastric, esophageal, and pancreatic cancer.
WNT7B is a signaling protein that activates the canonical Wnt/beta-catenin signaling pathway by binding to Frizzled receptors. It plays a role in placenta development, specifically the fusion of the chorion and allantois. It is also essential for blood vessel formation (angiogenesis) and the regulation of the blood-brain barrier in the central nervous system.
WNT7B is also known as -.
