WNT2
Description
The WNT2 (Wnt family member 2) is a protein-coding gene located on chromosome 7.
WNT2, encoded by the human gene WNT2, is a member of the WNT gene family, which consists of genes encoding secreted signaling proteins involved in the Wnt signaling pathway. This pathway is crucial for various developmental processes, including cell fate regulation and patterning during embryogenesis. WNT2 has been linked to oncogenesis. Different transcript variants have been identified for this gene.
WNT2 is a ligand for Frizzled receptors, activating the canonical Wnt signaling pathway and inducing transcription factors of the TCF/LEF family. It also regulates FGF10 expression, playing a crucial role in lung development. Additionally, WNT2 might contribute to brain development by controlling the proliferation of dopaminergic precursors and neurons.
WNT2 is also known as INT1L1, IRP.
Associated Diseases
- Parkinson disease
- lysosomal storage disease
- multiple sclerosis
- Alzheimer disease
- ovarian cancer
- low grade glioma
