WNT16
Description
The WNT16 (Wnt family member 16) is a protein-coding gene located on chromosome 7.
The WNT16 gene encodes the Wnt-16 protein, which is involved in cellular communication and development. It belongs to the WNT gene family, known for their role in various developmental processes and cancer. WNT16 has two transcript variants with different expression patterns. Variant 2 is primarily expressed in the pancreas, while variant 1 has wider expression, with highest levels in kidney, placenta, brain, heart, and spleen. After DNA damage, such as during chemotherapy or radiation, the WNT16B expression is regulated by NF-κB (nuclear factor of κ light polypeptide gene enhancer in B cells 1). This activated WNT16B then signals to nearby tumor cells, triggering the Wnt expression program, potentially contributing to chemotherapy resistance.
WNT16 is also known as -.
