WDR6
Description
The WDR6 (WD repeat domain 6) is a protein-coding gene located on chromosome 3.
WDR6 (WD repeat-containing protein 6) gene encodes a protein that belongs to the WD repeat protein family. These repeats are conserved regions of around 40 amino acids, typically marked by gly-his and trp-asp (GH-WD), which likely contribute to the formation of complex protein structures. WDR6 proteins are involved in various cellular functions, including cell cycle regulation, signal transduction, apoptosis, and gene regulation. WDR6 gene expression is widespread in adult and fetal tissues.
WDR6, in collaboration with FTSJ1, performs 2'-O-methylation of nucleotides at position 34 within the tRNA anticodon loop of substrate tRNAs. This methylation process requires WDR6 for precise positioning of the substrate tRNA. WDR6 also plays a role in suppressing autophagy triggered by amino acid starvation and enhances the growth inhibitory effect of STK11/LKB1. WDR6 interacts directly with FTSJ1, an interaction essential for the methylation of position 34 in substrate tRNAs. WDR6 also interacts with IRS4 and STK11/LKB1.
WDR6 is also known as Trm734.
