WDR43
Description
The WDR43 (WD repeat domain 43) is a protein-coding gene located on chromosome 2.
WDR43 is a protein that is involved in the formation of ribosomes. Ribosomes are essential for the production of proteins in the cell. WDR43 is a part of the small subunit (SSU) processome, which is a complex of proteins and RNA that is involved in the assembly of the small subunit of the ribosome. WDR43 is also involved in the regulation of gene expression. It is involved in the release of RNA polymerase II, which is an enzyme that is responsible for the transcription of DNA into RNA. This allows for the transcription of genes and the production of proteins.
WDR43 plays a crucial role in ribosome biogenesis, coordinating both transcription and the assembly of the small ribosomal subunit (SSU). It is a component of the SSU processome, a complex involved in the processing of pre-ribosomal RNA (pre-rRNA). During this process, WDR43 interacts with various factors to ensure proper pre-rRNA folding, modifications, rearrangements, and cleavage, ultimately contributing to the production of mature ribosomal subunits. This protein is also required for optimal pre-rRNA transcription by RNA polymerase I. Notably, WDR43 is essential for stem cell pluripotency and embryonic development. In addition to its role in ribosome biogenesis, WDR43 is involved in transcription regulation in the nucleoplasm. It interacts with promoters and facilitates the release of paused RNA polymerase II, leading to the elongation of transcription and increased expression of target genes.
WDR43 is also known as NET12, UTP5.
