WDFY4
Description
The WDFY4 (WDFY family member 4) is a protein-coding gene located on chromosome 10.
WDFY4 is involved in the process of cross-presentation of antigens from viruses and tumors by dendritic cells (specifically cDC1s). It works near the plasma membrane and interacts with endosomal membranes to help move antigens from the endosome into the cytosol. WDFY4 also plays a role in the survival of B-cells by regulating autophagy.
WDFY4 is also known as C10orf64.
Associated Diseases
- systemic lupus erythematosus
- primary familial polycythemia due to EPO receptor mutation
- alpha thalassemia-intellectual disability syndrome type 1
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- hemolytic anemia due to adenylate kinase deficiency
- erythrocytosis, familial, 3
- erythrocytosis, familial, 6
- Heinz body anemia
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- delta-beta-thalassemia
- hemoglobin E-beta-thalassemia syndrome
