VWA2
Description
The VWA2 (von Willebrand factor A domain containing 2) is a protein-coding gene located on chromosome 10.
VWA2 is the gene responsible for producing von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO). AMACO belongs to the von Willebrand factor A-like (VWA) domain containing protein superfamily and is characterized by three VWA-like domains, two EGF-like domains, a cysteine-rich domain, and a unique C-terminal domain. This protein is primarily located in the extracellular matrix, specifically near basement membranes. AMACO directly binds to FRAS1, a component of the Fraser complex, which plays a vital role in the interaction between epithelial and connective tissues. While AMACO's exact biological function remains unclear, its association with FRAS1 suggests a possible role in cell adhesion or tissue organization. In 2005, AMACO was found to be significantly upregulated in colon cancers, indicating its potential as a biomarker for this type of cancer.
The exact function of AMACO is still being investigated, but it is known to interact with FRAS1, a component of the Fraser complex, which plays a crucial role in epithelial-connective tissue interactions. AMACO's association with FRAS1 suggests a potential role in cell adhesion or tissue organization. Further research is needed to fully understand its biological significance.
VWA2 is also known as AMACO, CCSP-2, CCSP2, NET42.
