VIPR1
Description
The VIPR1 (vasoactive intestinal peptide receptor 1) is a protein-coding gene located on chromosome 3.
VIPR1, also known as VPAC1, is a protein encoded by the VIPR1 gene in humans. It is a receptor for vasoactive intestinal peptide (VIP), a small neuropeptide. VIPR1 is expressed in various tissues including the brain (cerebral cortex, hippocampus, amygdala), lung, prostate, peripheral blood leukocytes, liver, small intestine, heart, spleen, placenta, kidney, thymus, and testis. VIP plays a role in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. It acts via VIPR1 to inhibit megakaryocyte proliferation and induce proplatelet formation. VIPR1 has been implicated in the pathophysiology of certain diseases, such as idiopathic achalasia and stress urinary incontinence. Patients with idiopathic achalasia show variations in SNPs affecting VIPR1. Decreased levels of VIP and PACAP have been observed in patients with stress urinary incontinence and pelvic organ prolapse.
VIPR1, also known as VPAC1, is a receptor for vasoactive intestinal peptide (VIP). It is activated by G proteins, which in turn activate adenylyl cyclase. The affinity of VIPR1 for its ligands is VIP = PACAP-27 > PACAP-38.
VIPR1 is also known as HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIP-R-1, VIPR, VIRG, VPAC1, VPAC1R, VPCAP1R.
Associated Diseases
- spinocerebellar ataxia type 35
- spinocerebellar ataxia type 23
- urocanic aciduria
- hereditary spastic paraplegia 72
- autosomal dominant sensory ataxia 1
- spinocerebellar ataxia type 37
- spinocerebellar ataxia type 4
