VEZT
Description
The VEZT (vezatin, adherens junctions transmembrane protein) is a protein-coding gene located on chromosome 12.
VEZT is a gene located on chromosome 12 that encodes the protein vezatin. Vezatin is a key component of the cadherin-catenin complex, which is essential for forming and maintaining cell-cell junctions called adherens junctions. These junctions are crucial for the structure and function of tissues. Vezatin is expressed in most epithelial cells, which line the surfaces of organs and cavities. Mutations in VEZT can lead to either increased or decreased levels of vezatin, which can have negative effects on various bodily systems, especially during development. Vezatin plays a critical role in the formation and maintenance of adherens junctions in many epithelial cells. These junctions are composed of several proteins, including E-cadherin, alpha and beta catenins, actin, and myosin. E-cadherin molecules on separate cells use calcium to bind together, while the catenins connect the cadherins to the cell's internal framework, called the cytoskeleton. Vezatin is found at the same locations as E-cadherin, suggesting that it is involved in forming these junctions. E-cadherin is a vital transmembrane protein that helps create and maintain adherens junctions, particularly in epithelial cells.
VEZT plays a crucial role in forming and maintaining cell-cell junctions called adherens junctions, which are essential for tissue development and function. It is required for the early stages of embryonic development, specifically the formation and implantation of the embryo.
VEZT is also known as VEZATIN.
Associated Diseases
- uterine disorder
- cancer
- hemoglobin D disease
- Imerslund-Grasbeck syndrome type 2
- hemoglobin E disease
- Dent disease
