VAMP8
Description
The VAMP8 (vesicle associated membrane protein 8) is a protein-coding gene located on chromosome 2.
VAMP8 is a protein encoded by the VAMP8 gene in humans. It belongs to the vesicle-associated membrane protein (VAMP)/synaptobrevin family, known for their role in vesicle docking and fusion. VAMP8 is associated with perinuclear vesicular structures involved in early endocytosis. It interacts with the soluble NSF-attachment protein (alpha-SNAP), likely through a VAMP8-containing SNARE complex. Phosphorylation within the conserved SNARE domain can inhibit vesicle fusion. VAMP8 has been shown to interact with several other proteins, including STX4, SNAP23, STX1A, STX8, and STX7.
VAMP8 is a SNARE protein essential for membrane fusion in various cellular processes. It participates in autophagy by facilitating autophagosome fusion with lysosomes through interaction with the STX17-SNAP29 complex. VAMP8 is also crucial for dense-granule secretion in platelets, regulated enzyme secretion in pancreatic acinar cells, abscission during cell division, homotypic fusion of endosomes, and activation of type I interferon antiviral response via a TRIM6-dependent mechanism.
VAMP8 is also known as EDB, VAMP-8.
