VAMP7
Description
The VAMP7 (vesicle associated membrane protein 7) is a protein-coding gene located on chromosome X|Y.
VAMP-7, also known as SYBL1, is a transmembrane protein that belongs to the SNARE family. It is localized to late endosomes and lysosomes and plays a role in the fusion of transport vesicles with their target membranes. VAMP-7 interacts with SNAP23 and AP3D1.
VAMP7 plays a crucial role in the fusion of transport vesicles with their target membranes during the movement of proteins from the early endosome to the lysosome. It is essential for the heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion, as well as calcium-regulated lysosomal exocytosis. VAMP7 is involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi, and is necessary for exocytosis of mediators during eosinophil and neutrophil degranulation, along with target cell killing by natural killer cells. Additionally, it is required for focal exocytosis of late endocytic vesicles during phagosome formation.
VAMP7 is also known as SYBL1, TI-VAMP, TIVAMP, VAMP-7.
