UTP3
Description
The UTP3 (UTP3 small subunit processome component) is a protein-coding gene located on chromosome 4.
The UTP3 gene in humans encodes for silencing protein 10.
UTP3 is essential for gene silencing by playing a role in the structure of silenced chromatin. It is also involved in the development of the brain. As a component of the small subunit (SSU) processome, UTP3 is critical in the assembly of the small eukaryotic ribosomal subunit. Within the nucleolus, UTP3 interacts with various ribosome biogenesis factors, an RNA chaperone, and ribosomal proteins to facilitate RNA folding, modifications, rearrangements, cleavage, and the targeted degradation of pre-ribosomal RNA by the RNA exosome.
UTP3 is also known as CRL1, CRLZ1, SAS10.
