URI1
Description
The URI1 (URI1 prefoldin like chaperone) is a protein-coding gene located on chromosome 19.
URI1, also known as Unconventional prefoldin RPB5 interactor, is a protein encoded by the URI1 gene in humans. It binds to RNA polymerase II subunit 5 (RPB5) and negatively regulates transcription by interacting with RPB5. URI1 appears to have inhibitory effects on various activated transcription processes, but this requires its RPB5-binding region. It acts as a corepressor and may require signaling processes for its function or negatively modulate genes within the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. URI1 has been shown to interact with DMAP1 and STAP1.
URI1 plays a crucial role in regulating gene transcription. It acts as a transcriptional repressor, collaborating with the corepressor UXT to control androgen receptor (AR) transcription. This function might contribute to its potential tumor suppressor activity by suppressing AR-mediated gene transcription and inhibiting anchorage-independent growth in prostate cancer cells. Furthermore, URI1 is essential for cell survival in ovarian cancer cells. In conjunction with UXT, it binds to chromatin at the NKX3-1 promoter region. Additionally, URI1 counteracts transcriptional modulation by the hepatitis B virus X protein.
URI1 is also known as C19orf2, NNX3, PPP1R19, RMP, URI.
Associated Diseases
- Miyoshi myopathy
- cancer
- glycogen storage disorder due to hepatic glycogen synthase deficiency
- diabetes mellitus, permanent neonatal 4
- diabetes mellitus, transient neonatal, 3
- transient neonatal diabetes mellitus
- colorectal cancer
