UBXN2B
Description
The UBXN2B (UBX domain protein 2B) is a protein-coding gene located on chromosome 8.
UBXN2B plays a crucial role in the biogenesis of Golgi and endoplasmic reticulum (ER) by acting as an adapter protein. During interphase, it contributes to the maintenance of Golgi and ER, and at the end of mitosis, it aids in their reassembly. UBXN2B forms a complex with VCP, which possesses membrane fusion activity. This activity requires the tethering of USO1-GOLGA2 and the involvement of BET1L. VCPIP1 is also essential for this process, but its deubiquitinating activity is not required. UBXN2B, in collaboration with NSFL1C/p47, regulates the levels of AURKA/Aurora A kinase at the centrosomes during mitotic progression. It facilitates the removal of AURKA from centrosomes in prophase, thus impacting the regulation of spindle orientation during mitosis.
UBXN2B is also known as p37.
