UBP1
Description
The UBP1 (upstream binding protein 1) is a protein-coding gene located on chromosome 3.
Upstream-binding protein 1 is a protein that in humans is encoded by the UBP1 gene.
UBP1 acts as a transcriptional activator, but its activity is influenced by the specific promoter context. It plays a role in regulating the expression of CYP11A1 in the placenta. UBP1 also participates in regulating the alpha-globin gene within erythroid cells. This regulation occurs through synergistic interaction with TFCP2. Additionally, UBP1 binds strongly to sequences near the HIV-1 initiation site, while exhibiting weaker binding to the TATA box. This binding activity leads to the suppression of HIV-1 transcription by hindering the binding of TFIID to the TATA box.
UBP1 is also known as LBP-1B, LBP-1a, LBP1A, LBP1B.
Associated Diseases
- multiple sclerosis
- Parkinson disease
- Alzheimer disease
- lysosomal storage disease
- plasma fibronectin deficiency
- isolated asymptomatic elevation of creatine phosphokinase
- pentosuria
- hypoparathyroidism, familial isolated, 2
- pseudohypoparathyroidism type 2
