UBE2Z
Description
The UBE2Z (ubiquitin conjugating enzyme E2 Z) is a protein-coding gene located on chromosome 17.
UBE2Z, also known as USE1, is an enzyme encoded by the UBE2Z gene located on chromosome 17. It is ubiquitously expressed in many tissues and cell types. UBE2Z is an E2 ubiquitin conjugating enzyme that participates in the second step of protein ubiquitination during proteolysis. A genome-wide association study has linked UBE2Z to chronic kidney disease, and the gene contains one of 27 SNPs associated with increased risk of coronary artery disease. The UBE2Z gene spans 7 exons and produces 2 isoforms through alternative splicing. The protein consists of 246 amino acids, including a conserved 16–18 kDa ubiquitin conjugating enzyme E2 domain (UBC domain) at its N-terminal, responsible for its catalytic function.
UBE2Z is also known as HOYS7, USE1.
