UBE2V2
Description
The UBE2V2 (ubiquitin conjugating enzyme E2 V2) is a protein-coding gene located on chromosome 8.
UBE2V2, encoded by the UBE2V2 gene in humans, is a protein belonging to a distinct subfamily of E2 proteins. While resembling other ubiquitin-conjugating enzymes, UBE2V2 lacks the critical cysteine residue for E2 catalytic activity. It shares homology with UBE2V1 and the yeast MMS2 gene product. UBE2V2 acts as an intracellular sensor for reactive electrophilic species (RES), which are elevated during stress. The C69 residue of UBE2V2 binds RES, leading to UBE2V2-mediated activation of Ube2N. This activated Ube2N plays a key role in DNA damage responses, suggesting UBE2V2 promotes genome integrity by sensing RES and triggering these responses. It may also contribute to monocyte and enterocyte differentiation. UBE2V2 interacts with HLTF and, despite lacking ubiquitin-conjugating activity itself, facilitates the activity of other ubiquitin-conjugating enzymes through interaction.
UBE2V2, while lacking ubiquitin ligase activity on its own, forms a heterodimer with UBE2N. This complex catalyzes the synthesis of non-canonical poly-ubiquitin chains linked through 'Lys-63', a process that doesn't trigger protein degradation by the proteasome. It contributes to transcriptional activation of target genes and plays a role in cell cycle progression, differentiation, and error-free DNA repair, ultimately promoting cell survival after DNA damage.
UBE2V2 is also known as DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2.
