UBE2V1
Description
The UBE2V1 (ubiquitin conjugating enzyme E2 V1) is a protein-coding gene located on chromosome 20.
UBE2V1, also known as ubiquitin-conjugating enzyme E2 variant 1, is a protein encoded by the UBE2V1 gene in humans. It belongs to a distinct subfamily within the E2 protein family and shares sequence similarity with other ubiquitin-conjugating enzymes, but lacks the conserved cysteine residue required for catalytic activity. Located in the nucleus, UBE2V1 can activate transcription of the human FOS proto-oncogene and is thought to regulate differentiation through its influence on cell cycle behavior. Multiple alternatively spliced transcripts, encoding different isoforms, have been identified for this gene, along with a pseudogene also located on chromosome 20. Co-transcription of UBE2V1 and the neighboring upstream gene generates a rare transcript, Kua-UEV, which encodes a fusion protein containing sequences from both genes.
UBE2V1, also known as UEV-1, CROC-1, or TRAF6-regulated IKK activator 1 beta Uev1A, lacks ubiquitin ligase activity on its own. It forms a heterodimer with UBE2N, which catalyzes the synthesis of non-canonical poly-ubiquitin chains linked through Lys-63. This type of poly-ubiquitination activates IKK, but does not involve protein degradation by the proteasome. UBE2V1 plays a role in the activation of NF-kappa-B, mediated by IL1B, TNF, TRAF6, and TRAF2. It also mediates transcriptional activation of target genes and contributes to the control of cell cycle progression and differentiation. Furthermore, UBE2V1 is involved in the error-free DNA repair pathway and promotes cell survival after DNA damage. UBE2V1 enhances TRIM5 capsid-specific restriction activity by forming a heterodimer with UBE2N and interacting with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains that activate the MAP3K7/TAK1 complex, ultimately leading to the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. In collaboration with RNF135 and UBE2N, UBE2V1 catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI, activating the downstream signaling pathway that results in interferon beta production. Finally, UBE2V1-UBE2N, along with TRAF3IP2 E3 ubiquitin ligase, mediates 'Lys-63'-linked polyubiquitination of TRAF6, a component of the IL17A-mediated signaling pathway.
UBE2V1 is also known as CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A.
