UBE2S
Description
The UBE2S (ubiquitin conjugating enzyme E2 S) is a protein-coding gene located on chromosome 19.
UBE2S is an E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It specifically elongates 'Lys-11'-linked polyubiquitin chains, a type of ubiquitination that is crucial for the degradation of proteins by the proteasome. UBE2S plays a key role in the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls the progression through mitosis. It promotes the degradation of APC/C substrates by enhancing the elongation of 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10, thereby facilitating mitotic exit. Although it is also capable of elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro, the in vivo significance of this function remains unclear. Additionally, UBE2S is involved in the ubiquitination and degradation of VHL, which results in an accumulation of HIF1A. In vitro studies have shown that UBE2S can promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
UBE2S is also known as E2-EPF, E2EPF, EPF5.
Associated Diseases
- cancer
- breast cancer
- lung cancer
- brain glioma
- extraskeletal myxoid chondrosarcoma
- glioblastoma
- urinary bladder carcinoma
