UBE2L6
Description
The UBE2L6 (ubiquitin conjugating enzyme E2 L6) is a protein-coding gene located on chromosome 11.
Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1S), ubiquitin-conjugating enzymes (E2S) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
UBE2L6 catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. It plays a role in the E6/E6-AP-induced ubiquitination of p53/TP53 and promotes the ubiquitination and subsequent proteasomal degradation of FLT3.
UBE2L6 is also known as RIG-B, UBCH8.
