UBE2H
Description
The UBE2H (ubiquitin conjugating enzyme E2 H) is a protein-coding gene located on chromosome 7.
UBE2H is a human gene that encodes ubiquitin-conjugating enzyme E2 H. This enzyme plays a crucial role in the process of ubiquitination, where proteins are tagged for degradation. It belongs to the E2 ubiquitin-conjugating enzyme family, sharing a high degree of similarity with its counterparts in other species like mouse, frog, and zebrafish. Two distinct isoforms are produced from the UBE2H gene through alternative splicing.
UBE2H, also known as UbcH2, plays a crucial role in the ubiquitination process. It receives ubiquitin from the E1 complex and facilitates its attachment to other proteins. This enzyme participates in the transfer of ubiquitin to MAEA, a key component of the CTLH E3 ubiquitin-protein ligase complex. In laboratory settings, UBE2H has been shown to catalyze both 'Lys-11' and 'Lys-48' linked polyubiquitination. Additionally, it possesses the ability to ubiquitinate histone H2A in vitro.
UBE2H is also known as E2-20K, GID3, UBC8, UBCH, UBCH2.
