UBC
Description
The UBC (ubiquitin C) is a protein-coding gene located on chromosome 12.
The University of British Columbia (UBC) is a public research university with campuses near Vancouver and Okanagan, in British Columbia, Canada. Established in 1908, it is the oldest university in British Columbia. With an annual research budget of $747.3 million, UBC funds 9,675 projects annually in various fields of study within the industrial sector, as well as governmental and non-governmental organizations. The Vancouver campus is adjacent to the University Endowment Lands, an unincorporated area with multiple beaches and the Pacific Spirit Regional Park. The university is located 10 km (6 mi) west of downtown Vancouver. UBC is also home to TRIUMF, Canada's national particle and nuclear physics laboratory, which boasts the world's largest cyclotron. In addition to the Peter Wall Institute for Advanced Studies and the Stuart Blusson Quantum Matter Institute, UBC and the Max Planck Society collectively established the first Max Planck Institute in North America, specializing in quantum materials. One of Canada's largest research libraries, the UBC Library system has over 8.3 million items (including print and electronic) among its 21 branches. It is visited annually by 3.1 million people or 9.7 million virtually. The Okanagan campus, acquired in 2005, is located in Kelowna, British Columbia.
UBC (Ubiquitin C) exists in two forms: covalently attached to another protein or free (unanchored). When attached, it binds to target proteins via an isopeptide bond. It can exist as a monomer (monoubiquitin), a polymer linked via different Lys residues of ubiquitin (polyubiquitin chains), or a linear polymer linked via the initiator Met (linear polyubiquitin chains). The function of polyubiquitin chains depends on the linked Lys residue: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses, and signaling processes leading to NF-kappa-B activation. Linear polymer chains formed by attachment via the initiator Met lead to cell signaling. Although typically conjugated to Lys residues, UBC can also attach to Cys or Ser residues in rare cases. Unanchored-polyubiquitin plays distinct roles, such as activating protein kinases and signaling.
UBC is also known as HMG20.
