UBA6
Description
The UBA6 (ubiquitin like modifier activating enzyme 6) is a protein-coding gene located on chromosome 4.
UBA6 activates ubiquitin by adenylating its C-terminal glycine residue with ATP, then linking this residue to a cysteine residue in E1, forming a ubiquitin-E1 thioester and AMP. UBA6 is specific for ubiquitin and does not activate ubiquitin-like peptides. Unlike UBE1, UBA6 has a different specificity for substrate E2 charging and does not charge cell cycle E2s like CDC34. It is essential for embryonic development and required for UBD/FAT10 conjugation. Isoform 2 may play a key role in the ubiquitin system and influence spermatogenesis and male fertility.
UBA6 is also known as E1-L2, MOP-4, UBE1L2.
