UACA
Description
The UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) is a protein-coding gene located on chromosome 15.
UACA (Uveal autoantigen with coiled-coil domains and ankyrin repeats) is a human protein encoded by the UACA gene. It is associated with Graves' Disease and is involved in signaling by Rho GTPases and the intrinsic pathway for apoptosis. An important paralog of UACA is ANKRD24.
UACA regulates the expression of APAF1, a key component of the apoptosome, and plays a crucial role in stress-induced apoptosis. It promotes apoptosis through multiple mechanisms, including upregulating the apoptosome, downregulating LGALS3/galectin-3, and inactivating NF-kappa-B. UACA also controls the redistribution of APAF1 into the nucleus following proapoptotic stress and downregulates LGALS3 expression by inhibiting NFKB1.
UACA is also known as NUCLING.
