TXN
Description
The TXN (thioredoxin) is a protein-coding gene located on chromosome 9.
TXN may refer to: Thioredoxin (Trx), also know as ATL-derived factor, Surface-associated sulphydryl protein. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity (PubMed:16408020, PubMed:17606900). Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (PubMed:11118054, PubMed:9108029). ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). Homodimer; disulfide-linked (PubMed:17260951, PubMed:9369469). Interacts with TXNIP through the redox-active site (PubMed:17260951). Interacts with MAP3K5 and CASP3 (PubMed:15246877). In case of infection, interacts with S.typhimurium protein slrP (PubMed:19690162). Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (PubMed:9108029).
TXN participates in various redox reactions by reversibly oxidizing its active center dithiol to a disulfide, catalyzing dithiol-disulfide exchange reactions. It also plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, contributing to the response to intracellular nitric oxide. TXN nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), inhibiting caspase-3 activity. Additionally, TXN induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status, stimulating AP-1 transcriptional activity.
TXN is also known as TRDX, TRX, TRX1, TXN1, Trx80.
